I obtained my PhD in Cancer Cell biology at King’s College London under the supervision of Prof Anne Ridley. My PhD work focused on understanding the role Rho GTPases in T-ALL cell migration. In 2012 I moved to Paris for a postdoc in the laboratory of Dr Philippe Chavrier at the Institut Curie where I worked on understanding how cancer cells use their degradative machinery in order to remodel the extracellular matrix and invade. I joined the laboratory of Dr Sergi Garcia-Manyes to undertake an interdisciplinary project combining different techniques such as single cell atomic force microscopy and magnetic tweezers to elucidate the mechanisms of cellular mechanotransduction.
Jim Yong Jian Wang
I have a Ph.D in polymer physics. My research interests focus on force related phenomena at the surface/interface at multiscale systems in both physics and biology. I have studied dewetting instability of polymer thin film, contact angle hysteresis, and membrane protein assembling. During my research, I also developed AFM based capillary force apparatus, and SFA/FRET system which integrates surface force apparatus (SFA) with Foster Resonant Energy Transfer (FRET) imaging. In Garcia-Manyes lab, I work in mechanobiology, studying mechanical force related functions of protein and protein complex.
Andrew Stannard I completed my PhD, titled Pattern Formation in Nanostructured Systems, in September 2009 under the supervision of Prof. Moriarty in the School of Physics and Astronomy at the University of Nottingham, where I remained as an independent Research Fellow for five years, sequentially holding EPSRC PhD Plus, Leverhulme Trust Early Career, and Nottingham Advanced Research Fellowships, and gaining promotion to Senior Research Fellow in 2013. My research revolved around utilizing experimental and computational techniques towards the advancement of scanning probe microscopy of, and the self-assembly processes in, a wide range of nanomaterials. In 2014 I took a break from academia to pursue my passion for equality in education, and commenced secondary school teacher training in the pilot cohort of the Researchers in Schools programme, placing postdoctoral researchers into schools with low social mobility and poor university participation rates. As such, I become a Teacher of Science at Barnhill Community High School in West London and an Honorary Research Associate at King’s College London. I’ve now returned to academia to work in the laboratory of Prof. Garcia-Manyes, part of the Experimental Biophysics and Nanotechnology group in the Department of Physics at King’s College London. http://andrewphysics.jimdo.com/
In 2012 I obtained my BSc in physics and mathematics from the University of Leeds and in 2013 completed my MRes in molecular biophysics from Kings College London. I conducted my PhD in the Garcia-Manyes lab, using force spectroscopy to investigate mechanochemistry at the single bond level.
Marc Mora Hortal
I obtained my Chemistry degree from the University of Barcelona in 2015. During my time here, I undertook a research project in the Self Organized Complexity and Self Assembled Material group, investigating chiral structures in liquid crystals. My PhD in the Garcia-Manyes lab is funded by Fight for Sight, and the main goal of my research is to use single molecule force-clamp spectroscopy to capture the molecular onset of protein misfolding.
Sam Gulaidi Breen
I am currently a project student enrolled on the molecular biophysics MRes at KCL. My project couples Atomic force microscopy and fluorescence microscopy to investigate cellular nanobiomechanics, and the effects of force on nuclear mechanotransduction. I obtained my BSc in biochemistry at UEA, where I worked on a research project in which I studied the protein-protein interactions of a membrane bound multi-heme cytochrome known as CymA in Shewenella Oneidensis MR-1. Upon completion of my masters, I will begin my PhD studentship at the Francis Crick institute. There, I will undergo a project investigating the unfolding pathways of individual membrane proteins in a lipid bilayer using single molecule force techniques. This project will be under the supervision of Dr Justin Molloy, and Professors Paula Booth and Sergi Garcia-Manyes.
I studied Biochemistry at Nottingham Trent University, graduating in 2013. I then completed my MSc in Molecular Cell Biology at the University of Sussex in 2017. My research project was carried out in the lab of Dr Erika Mancini, investigating Protein-Protein interactions for drug discovery efforts. My role as a research technician in the Garcia-Manyes group involves preparation and purification of the polyprotein constructs which are later studied by force spectroscopy.
Ainhoa Lezamiz Herrero
I am a Biochemist with a Master’s degree in Molecular Biology and Biomedicine. I joined the group for taking care of our “protein factory” in the Randall Division of Cell & Molecular Biophysics. In this molecular biology section we prepare the constructs of our polyproteins, optimize their expression and complete the purifications so they are ready for being pulled on the AFMs.
Palma Rico Lastres
I studied Biology at the University of Alicante (Spain). After two years as a molecular biology technician I started working on my thesis project under the supervision of Dr. Margarita Menéndez at the Insitute of Physical Chemistry “Rocasolano” (CSIC-IQFR) in Madrid. In 2015 I obtained my Ph.D. from the Complutense University of Madrid and then I joined the molecular biology section of the Garcia-Manyes group as a Research Technician. My current work is the preparation, expression, and purification of the polyprotein constructs, for being later studied by AFM.
- David Giganti
- Aisling Williams
- Bob-Dan Lechner
- Marta Castro-Lopez
- Josep Relat-Goberna
- Judit Perales-Calvo