Beedle, A. E., Mora, M., Lynham, S., Stirnemann, G., Garcia-Manyes, S. «Tailoring protein nanomechanics with chemical reactivity» Nature Communications (2017), 8, 15658. Link  PDF: ncomms15658

Relat-Goberna, J., Beedle, A.E.M., Garcia-Manyes, S. «The nanomechanics of lipid multibilayer stacks exhibits complex dynamics» Small (2017), 13, 1700147. Link PDF: Relat-Goberna_et_al-2017-Small

Pernigo, S., Fukuzawa, A., Beedle, A.E.M., Holt, M., Round, A., Pandini, A., Garcia-Manyes, S., Gautel, M., Steiner, R.A. «Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection » Structure (2017), 25, 107-120. PDF: 2017Structure


Beedle, A. E.; Lynham, S.;  Garcia-Manyes, S. « Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding » Nature Communications (2016), 7, 12490. Link. PDF: ncomms12490


Garcia-Manyes, S.; Giganti,D.; Badilla, C. L.; Lezamiz, A.; Perales-Calvo, J.; Beedle, A. E.; Fernandez, J. M. «Single molecule force spectroscopy predicts a misfolded domain-swapped conformation in the human γD- crystallin » The Journal of Biological Chemistry  (2015) DOI: jbc.M115.673871. Link  PDF: J. Biol. Chem.-2015

Beedle, A. E.; Williams, A.; Relat-Goberna, J.; Garcia-Manyes, S. «Mechanobiology – chemical origin of membrane mechanical resistance and force-dependent signaling » Current Opinion in Chemical Biology (2015), 29, 87-93. Link PDF: 2015currentopinion

Perales-Calvo, J.; Lezamiz, A.; Garcia-Manyes, S. « The mechanochemistry of a structural zinc finger » The Journal of Physical Chemistry Letters (2015), 6, 3335-3340. Link PDF: PeralesCalvo-PhysChemLett
ACS Editors Choice

Beedle, A. E.; Lezamiz, A.; Sitrnemann, G.; Garcia-Manyes, S. « The mechanochemistry of copper reports on the directionality of unfolding in model cupredoxin proteins » Nature Communications (2015), 6, 7894. Link PDF: ncomms8894

Relat-Goberna, J.; Garcia-Manyes, S. «Direct observation of the dynamics of self-assembly of individual solvation layers in molecularly confined liquids » Phys. Rev. Lett (2015), 114 (25) 258303. Link PDF: PhysRevLett.114.258303


Atilla-Gokcumen, G.; Muro, E.; Relat-Goberna, J.; Sasse, S.; Bedigian, A.; Coughlin, M.; Garcia-Manyes, S.; Eggert, U. «Dividing cells regulate their lipid composition and localization» Cell (2014), 3, 428-439. PDF: Cell2014


Popa, I; Kosuri, P.; Alegre-Cebollada, J.; Garcia-Manyes, S.; Fernandez, J.M. «Force dependency of biochemical reactions measured by single molecule force-clamp spectroscopy» Nature Protocols (2013), 8, 1261-1276. pdf: nprot.2013-Popa

Berkovich, R.; Hermans, R.I.; Popa, I.; Stirnemann, G.; Garcia-Manyes, S.; Berne, B.J.; Fernandez, J.M; «Rate limit of protein elastic response is tether dependent» Proc. Natl. Acad. Sci. USA, (2012), 109 (36) 14416-14421. pdf: PNAS-2012-Berkovich

Garcia-Manyes, S*; Badilla, C.L.; Alegre-Cebollada, J.; Javadi, Y.; Fernandez, J.M. «Spontaneous dimerization of the titin Z1-Z2 domains induces a strong nano-mechanical anchorin», Journal of Biological Chemistry (2012); 287 (24) 20240-20247. pdf: JBC-2012-Garcia-Manyes

Popa, I; Fernández, J.M.; Garcia-Manyes, S.*; «Direct quantification of the attempt frequency determining the mechanical unfolding of ubiquitin protein», Journal of Biological Chemistry (2011); 286 (36), 31072-31079. pdf: JBC-2012-Popa

Garcia-Manyes, S*; Kuo, TL.; Fernández, J.M., «Contrasting the individual reactive pathways in protein unfolding and disulfide bond reduction observed within a single protein», Journal of the American Chemical Society (2011), 133 (9), 3104-3113. pdf: JACS-2011-Garcia-Manyes

Perez-Jimenez, R.; Inglés-Prieto, A.; Zhao, Z.M.; Sanchez-Romero, I.; Alegre-Cebollada J.; Kosuri, P.; Garcia-Manyes, S.; Holmgren, A.; Kappock, T.J.; Tanokura, M.; Sanchez-Ruiz J.M.; Gaucher, E.A.; Fernandez, J.M., «Paleoenzymology at the single-molecule level: probing the chemistry of resurrected enzymes», Nature Structural & Molecular Biology (2011), 18, 592-596. pdf: NSMB-2011-Perez-Jimenez


Garcia-Manyes, S*; «Caught in the act», Nature Chemistry, (2010), 2, 905-906. pdf:

Garcia-Manyes, S.*; Redondo-Morata, L.; Oncins, G.; Sanz, F.; «Nanomechanics of lipid bilayers: heads or tails?», Journal of the American Chemical Society (2010), 132 (7) 12874-12886. pdf: JACS-2010-Garcia-Manyes

Berkowitz, R.; Garcia-Manyes, S.; Klafter, J.; Urback, M.; Fernández, J.M.; «Hopping around an entropic barrier created by force», Biochemical and Biophysical Research Communications (2010), 403, 133-137. pdf: BBRC-2010-Garcia-Manyes

Kuo, TL.; Garcia-Manyes, S.; Li, J.; Barel, I.; Lu, H.; Berne, B.J.; Urbakh, M.; Klafter, J.; Fernández, J.M., «Probing disorder in Arrhenius with single molecule force spectroscopy», Proc. Natl. Acad. Sci. USA, (2010), 107 (25) 11336-11340. pdf: PNAS-2010-Kuo

Berkowitz, R.; Garcia-Manyes, S.; Klafter, J.; Urback, M.; Fernández, J.M.; «Collapse dynamics of single proteins extended by force», Biophysical Journal, 2010, 98, 2692-2701. pdf: BJ-2010-Garcia-Manyes

Garcia-Manyes, S.*; Sanz, F.; «Nanomechanics of lipid bilayers by force spectroscopy with AFM: a perspective», Biochimica et Biophysica Acta: Biomembranes, (invited review), (2010), 1798, 741-749. pdf: BBA-2010-Garcia-Manyes

Garcia-Manyes, S.*; Dougan, L.; Fernandez, J.M.; «Osmolyte induced separation of the mechanical folding phases of ubiquitin», Proc. Natl. Acad. Sci. USA, (2009), 106 (26)10540-10545. pdf: PNAS-2009-Garcia-Manyes2

Garcia-Manyes, S.*; Dougan, L.; Badilla, C. L.; Brujic, J; Fernandez, J.M.; «Direct observation of an ensemble of stable collapsed states in the mechanical folding of ubiquitin», Proc. Natl. Acad. Sci. USA, (2009), 106 (26),10534-10539. pdf: PNAS-2009-Garcia-Manyes1

Garcia-Manyes, S.*; Liang, J.; Szoszkiewicz, R.; Kuo, T.; Fernandez, J.M.; «Force-activated reactivity switch in a bimolecular chemical reaction», Nature Chemistry, (2009), 1, 236-242. Featured in the News and Views of the same issue, Frank, I and Hofbauer, F., Nature Chemistry (2009) 1, 180-181. pdf: NChem-2009-Garcia-Manyes

Fernandez, J.M., Garcia-Manyes, S.; Dougan, L. «Force-clamp spectroscopy of single proteins», in Single Molecule Spectroscopy in Chemistry, Physics and Biology: Nobel Symposium, Edited by Astrid Gräslund, Rudolf Rigler and Jerker Widengren (Springer Series in Chemical Physics), 2009.

Liu, R.; Garcia-Manyes*, S.; Sarkar, S.; Badilla, C.L.; Fernandez, J.M.; «Mechanical characterization of Protein L in the low-force regime by electromagnetic tweezers/evanescent nanometry», Biophysical Journal, (2009), 96, 3810-3821. pdf: BJ-2009-Garcia-Manyes

Grüntzer, A.; Garcia-Manyes, S.; Badilla, C.L., Fernandez, J.M.; Linke, W.A.; «Modulation of titin-based stiffness by dislufide bonding in the cardiac titin N2B unique sequence», Biophysical Journal, (2009), 97, 825-834. pdf: BJ-2009-Grutzner

Garcia-Manyes, S.; Brujic, J.; Badilla, C. L.; Fernandez, J. M.; «Force-clamp spectroscopy of single protein monomers reveal the individual unfolding and folding pathways of I27 and ubiquitin», Biophysical Journal (2007), 93, 2436-2446. pdf: BJ-2007-Garcia-Manyes

Brujic, J.; Hermans, R.I.Z.; Garcia-Manyes, S.; Walther, K.A.; Fernandez, J. M.; «Dwell-time distribution analysis of polyprotein unfolding using ‘Force-Clamp’ Spectroscopy», Biophysical Journal (2007), 92, 2896-2903. pdf: BJ-2007-Brujic

Perez-Jimenez, R.; Garcia-Manyes, S., Ainavarapu, S.R.K, Fernandez, J.M., «Mechanical Unfolding Pathways of the Enhanced Yellow Fluorescent Protein Revealed by Single Molecule Force Spectroscopy», Journal of Biological Chemistry (2006), 281 (52), 40010-40014.


Garcia-Manyes, S.; Bucior, I.; Ros, R.; Anselmetti, D:; Sanz, F.; Burger, M. M.; Fernandez-Busquets, X., «Cell adhesion in the oldest extant Metazoans is based on strong interactions of allotypic glycans that can discriminate self from non-self» Journal of Biological Chemistry (2006), 281 (9), 5992-5999.

Garcia-Manyes, S.; Gorostiza, P.; Sanz, F., «Titration force microscopy on supported lipid bilayers», Analytical Chemistry (2006), 78, 61-70.

Garcia-Manyes, S.; Oncins, G.; Sanz, F., «Effect of temperature on the nanomechanics of lipid bilayers studied by Force Spectroscopy», Biophysical Journal (2005), 89 (6), 4261-4274.

Garcia-Manyes, S.; Oncins, G.; Sanz, F., «Effect of ion-binding and chemical phospholipid structure on the nanomechanics of lipid bilayers studied by Force Spectroscopy», Biophysical Journal (2005), 89 (3), 1812-1826.

Morant, C.; Garcia-Manyes, S.; Sanz, F.; Sanz, J. M.; Elizalde, E., «Nanotribological properties of CN/TiCN/TiN/Si multilayer as determined by AFM», Nanotechnology (2005), 16, 211-217.

Oncins, G.; Garcia-Manyes, S.; Sanz, F., «Study of Frictional Properties of 1,2-Dimyristoyl-sn-glycero-3-phosphocholine Bilayers in Liquid Environment», Langmuir (2005), 21, 7373-7379.

Garcia-Manyes, S., Güell, A. G.; Gorostiza, P.; Sanz, F., «Nanotribological properties of CN/TiCN/TiN/Si multilayer as determined by AFM», Journal of Chemical Physics (2005), 123, 114711. (Also selected by the Virtual Journal of Nanoscale Science & Technology (2005), 12, 14).

Garcia-Manyes, S.; Verdaguer, A.; Gorostiza, P.; Sanz, F., «Alkali Halide Nanocrystal Growth and Etching Studied by AFM and Modeled MD Simulation», Journal of Chemical Physics (2004), 120, 6, 2963-2971.

Fraxedas, J.; Garcia-Manyes, S.; Gorostiza, P.; Sanz, F., «Nanoindentation: towards the sensing of atomic interactions», Proc. Natl. Acad. Sci. USA (2002), 99, 5228-5232.


Garcia-Manyes, S.; Jiménez, G.; Padró, T.; Rubio, R.; Rauret, G., «Arsenic speciation in contaminated soils», Talanta (2002), 58, 97-109.